Acanthosis nigricans
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Este frecvent la persoanele obeze.
References
Acanthosis nigricans este o manifestare cutanată a unei afecțiuni de bază. Apare adesea în pliurile pielii, cum ar fi gâtul, axilele și zona inghinală, arătând ca pete întunecate catifelate, cu margini neclare. Această afecțiune este de obicei legată de diabet și rezistență la insulină, dar în cazuri rare, ar putea indica cancer în interiorul corpului. De asemenea, poate apărea din cauza problemelor hormonale sau de la administrarea de medicamente specifice, cum ar fi steroizi și pilulele contraceptive.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) este o afecțiune comună a pielii, legată de diverse probleme de sănătate, cum ar fi rezistența la insulină, diabetul, obezitatea, anumite tipuri de cancer, problemele hormonale și reacțiile la medicamente. Tratarea AN se concentrează pe abordarea problemelor de sănătate subiacente. Inițial, medicii verifică semnele sindromului de rezistență la insulină, care includ obezitatea, colesterolul crescut, hipertensiunea arterială și diabetul de tip 2. Medicii prescriu adesea topical retinoids ca primă alegere de tratament, care poate ajuta la îngroșarea pielii. Cu toate acestea, este posibil să nu abordeze pe deplin întunecarea pielii. Alte opțiuni de tratament, cum ar fi salicylic acid, podophyllin, urea, and calcipotriol , necesită, de asemenea, aplicare frecventă.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Cauze
Apare de obicei la indivizi mai tineri de 40 de ani, poate fi moștenit genetic și este asociat cu obezitate sau endocrinopatii, cum ar fi hipotiroidismul, acromegalia, boala ovarelor polichistice, diabetul rezistent la insulină sau boala Cushing.
○ Tratament - Medicamente OTC
#40% urea cream